Achilleas Gravanis

Professor of Pharmacology                Collaborative Researcher

Faculty of Medicine                              IMBB-FORTH

University of Crete


Dept of Pharmacology, Medical School, University of Crete, Heraklion, 71110, Greece

PHONES          : +30 2810 394521 (Lab), +30 2810 392590  (Hospital)

FAX                  : +30 2810 394530,     E-mail:



1975-1980 Diploma of Pharmacy, School of Pharmacy, University of Athens,  Greece

1980-1983 PhD in Pharmacology, University Pierre et Marie Curie, Paris, France

1983-1986 Research Associate, Mount Sinai School of Medicine, New York, U.S.A

1987-1991 Assistant Professor of Pharmacology, Medical School University of Crete

1991-2001 Associate Professor of Pharmacology, Medical School, University of Crete

2000-2001 Chairman, Dept. of Basic Sciences, Medical School, University of Crete

2001          Professor of Pharmacology, Medical School, University of Crete

2002-2008 Director, Laboratory of Clinical Pharmacology, University Hospital of Heraklion

2010          Researcher, IESL-Foundation of Research & Technology-Hellas (FORTH)

2014          Researcher, Institute of Molecular Biology & Biotechnology (IMBB), FORTH


Molecular interactions of synthetic Microneurotrophins with                 Neural cells and neural ganglia cultured in 3D silicon scaffolds      

TrkA receptor of Nerve Growth Factor                                                                      (Simitzi et el, Biomaterials 2015)

(Pediaditakis et al Neuropharmacology 2016)

Brain hormonal micro-environment and neurotrophins during development and aging. Molecular mechanisms in neurodegeneration and neurogenesis: development of synthetic small molecules with neuroprotective and neurogenic properties. Bioengineering of 3D scaffolds for neuronal cell cultures: development of neuroimplants and neurobiosensors.

Blood-brain-barrier permeable 17-spiro-steroid derivatives bind to and activate neurotrophin receptors,

protecting various neurons against apoptosis, in vitro, ex vivo and in vivo in animal models of neurodegenerative diseases. These synthetic Microneurotrophins offer a new pharmacological tool to develop non-toxic, blood-brain-barrier permeable neurotrophin receptor agonists and antagonists, potentially effective in the treatment of neurodegenerative diseases, brain trauma and neuropathic pain (Gravanis et al, Oncotarget 2016).


1995          Member of the Project Review Board of BIOMED 2 program, European Union (EU). 

1996          Member of the 5-year Assessment Committee of BIOMED 1 program, (EU)

1996          Member of the 1996 Monitoring Committee of BIOMED 2 program (EU)

1998          Member of the BIOMED 2 Assessment Committee (EU)

2001          Co-Chairman of the BIOMED 2 Assessment Committee (EU), Brussels

2000-2003 Greek National Delegate Program Committee Life Sciences-Genomics Research FP6, (EU),

2003          Member of the Genomics Assessment Committee of FP5, (EU),

2005:         Member of the Steering Committee, Population Genomics-Pharmacogenomics, Welcome Trust-EU

2006-2010 Member of the Fellowships Committee της Federation European Biochemical Societies (FEBS)

2007           External Reviewer Panel LS5, European Research Council (ERC)

2009-2010  Greek National Expert Program Committee, FP7-Heath-Cooperation (EU)

2008-2011  Member of the Council, Hellenic Quality Assurance Agency for Higher Education (HQAA).

2003           Co-founder, member of the BoD, Bionature EA Ltd, biotech spinoff/University of Crete (

2011           Chairman, Research Committee of Biosciences, Hellenic National Council of Research & Technology 

2011           Member of the Hellenic National Council of Public Health

2016           Affilated Research Professor, Center of Drug Discovery Northeastern University (

2016          Visiting Professor, Medical School European University of Cyprus (

2016         Scientific Collaborator-Advisor, Emulate SA, WYSS/Harvard spinoff (

2017         Member of the Scientific Board, Hellenic Foundation of Research & Innovation (ELIDEK)

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